Marble Burying Problems

However some investigators incorporate the sub acute treatment regimen as an essential component for screening anti compulsive agents.

Marble burying problems.

Marble burying the marble burying test is a useful model of neophobia 1 anxiety 1 7 and obsessive compulsive behavior 8 11. 1 3 since the bulk of this work was done using female mice the 1 1 ns finding that males have the same propensity to bury marbles shows 1 5 ns that the behavior is not peculiar to. While widely used there is significant controversy over the interpretation of its results. The 1 3 ns finding that marble burying was constant across several exposures at different times of day suggests that burying behavior has no clear diurnal pattern.

It has also been proposed that the test may have predictive validity for the screening of novel antidepressants 12 15 anxiolytics 15 16 and antipsychotics 17 19. The marble burying test is commonly used to quantify anxiety obsessive compulsive or repetitive behaviour in rodents 1 3 performance on the marble burying test is also associated with general digging behaviour 4 7 and so the underlying construct being measured is still unclear regardless the typical protocol places 10 25 marbles in a cage containing sawdust or similar. However modulation of marble burying by serotonin reuptake inhibitors prompted its link to obsessive compulsive disorder compulsive like behavior. It is based on the observation that rats and mice will bury either harmful or harmless objects in their bedding.